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. 1993 Jul 8;364(6433):121-6.
doi: 10.1038/364121a0.

Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast

M M Wang  1 , R R Reed
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Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast

M M Wang et al. Nature. .

Abstract

A novel genetic selection in yeast has been used to isolate a complementary DNA for the transcriptional activator, Olf-1, which binds to the regulatory sequences of several olfactory-specific genes. The Olf-1 protein, expressed exclusively in the olfactory receptor neurons and their precursors, contains a new helix-loop-helix motif and functions as an apparent homodimer. Olf-1 may be the first member of a family of related proteins that may direct cellular differentiation in a variety of neuronal tissues.

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