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. 1977 Jan;39(1):267-73.
doi: 10.1002/1097-0142(197701)39:1<267::aid-cncr2820390141>3.0.co;2-x.

Familial polyposis

J J DeCosse, M B Adams, R E Condon

Familial polyposis

J J DeCosse et al. Cancer. 1977 Jan.

Abstract

Familial polyposis is a genetically-transmitted disease characterized by multiple adenomatous colorectal polyps and a high risk for development of adenocarcinoma. Familial polyposis and Gardner's syndrome should be differentiated from other penetically-linked polyposis syndromes lacking a predisposition for cancer. Total colectomy and ileorectal anastomosis, aggressive follow-up and intensive surveillance of non-polyp bearing relatives can reduce the risk of developing cancer. From an epidemiologic point of veiw, polyposis is a valuable model for the study of the interaction of genetic and environmental factors in the genesis of colon cancer.

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