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. 1993 Spring:39-40:445-53.
doi: 10.1007/BF02919009.

Gene manipulation by protoplast fusion and penicillin production by Penicillium chrysogenum

M K Tahoun  1
Affiliations

Gene manipulation by protoplast fusion and penicillin production by Penicillium chrysogenum

M K Tahoun. Appl Biochem Biotechnol. 1993 Spring.

Abstract

Hybrids have been obtained by protoplast fusion of nitrate-nonutilizing cnx- and acetate-nonutilizing fac- mutants of Penicillium chrysogenum strains 4/95 and 26/818, respectively. Induced haplodization of the hybrids allowed the recovery of stable segregants, which were screened for penicillin production. The penicillin-producing segregants showed a wide range of titers that reached for a certain mutant to 290-390% increase above the parent strains.

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