Effects of neonatal ablation of area 18 on corticocortical projections from area 17 to extrastriate visual areas in cats

Abstract

Using retrogradely transported fluorescent dyes, we investigated the distributions of corticocortical neurones in area 17 projecting to area 19 and to the lateral suprasylvian visual area in a normal cat and two cats in which area 18 had been ablated at 4 days old. Cells projecting to area 19 were distributed in a much more continuous manner in the lesioned cats than in the normal one, whereas those projecting to the lateral suprasylvian cortex were located in discrete patches in all three cats. Neonatal ablation of area 18 can thus prevent the normally occurring developmental removal of neurones or their axons projecting from area 17 to area 19, but not the removal occurring in the projection from area 17 to the lateral suprasylvian cortex.