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. 1977;23(1):32-6.
doi: 10.1159/000221968.

Bactericidal synergistic effect due to chloramphenicol-induced inhibition of staphyloccal penicillinase

J Michel, J Jacobs, T Sacks

Bactericidal synergistic effect due to chloramphenicol-induced inhibition of staphyloccal penicillinase

J Michel et al. Chemotherapy. 1977.

Abstract

A synergistic bactericidal effect of chloramphenicol and penicillin-G was observed with 17 out of 20 beta-lactamase producing strains of Staphylococcus aureus. The synergism was due to chloramphenicol-induced inhibition of beta-lactamase production. With seven of the strains the synergistic effect was operative only with subinhibitory concentrations of chloramphenicol, while higher concentrations produced antagonism.

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