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Case Reports
. 1978 Nov 24;45(1):85-8.
doi: 10.1007/BF00277578.

Anencephaly in trisomy 18 associated with elevated alpha-1-fetoprotein in amniotic fluid

U Merrild, V Schiøler, F Christensen, E Wolny, C J Edeling
Case Reports

Anencephaly in trisomy 18 associated with elevated alpha-1-fetoprotein in amniotic fluid

U Merrild et al. Hum Genet. .

Abstract

Elevated levels of alpha-1-fetoprotein (AFP) were found in the amniotic fluid of a 36-year-old woman in the 15th week of gestation. Because of this and the results of repeated ultrasonography, abortion was induced. An anencephalic fetus with trisomy 18 was delivered. The possible correlation among neural-tube defects, chromosomal abnormalities, and level of AFP is discussed.

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