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Comparative Study
. 1993 Jun;37(6):1313-7.
doi: 10.1128/AAC.37.6.1313.

Inactivation of rifampin by Nocardia brasiliensis

K Yazawa  1 , Y Mikami, A Maeda, M Akao, N Morisaki, S Iwasaki
Affiliations
Comparative Study

Inactivation of rifampin by Nocardia brasiliensis

K Yazawa et al. Antimicrob Agents Chemother. 1993 Jun.

Abstract

Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the Nocardia species.

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