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Comparative Study
. 1993 Jun;37(6):1364-6.
doi: 10.1128/AAC.37.6.1364.

In vitro activity of ramoplanin against vancomycin-resistant gram-positive organisms

L A Collins  1 , G M Eliopoulos, C B Wennersten, M J Ferraro, R C Moellering Jr
Affiliations
Comparative Study

In vitro activity of ramoplanin against vancomycin-resistant gram-positive organisms

L A Collins et al. Antimicrob Agents Chemother. 1993 Jun.

Abstract

In vitro activity of ramoplanin, a cyclic lipoglycopeptide, against 92 vancomycin-resistant gram-positive organisms was evaluated. Ramoplanin demonstrated potent activity against many highly vancomycin-resistant organisms including enterococci (MICs for 90% of strains tested of 0.5 micrograms/ml) and against Lactobacillus spp., Leuconostoc spp., and Pediococcus spp., all of which were inhibited at concentrations of < or = 0.25 micrograms/ml. This drug or a derivative compound merits further investigation as a potential therapeutic agent for infections due to vancomycin-resistant enterococci.

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References

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