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Comparative Study
. 1993 Jul 18;1174(1):111-3.
doi: 10.1016/0167-4781(93)90103-k.

Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein

A Chellaiah  1 , A Davis, T Mohanakumar
Affiliations
Comparative Study

Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein

A Chellaiah et al. Biochim Biophys Acta. .

Abstract

A human homologue of the bacterial DNAJ heatshock protein, HDJ-2, was isolated from a human umbilical vein endothelial cDNA library using a monoclonal antibody which reacts specifically to human endothelial cells and monocytes. This cDNA clone consists of 1469 nucleotides with an open reading frame of 1191 nucleotides. HDJ-2 shares significant homology with Escherichia coli heat shock protein DNAJ, as well as the yeast homologues Sec63, YDJ1, SCJ1 and SIS1. This homology suggests HDJ-2 may be involved in protein folding and/or transport.

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