Histocompatibility difference between C3HfeB/HeN and C3H/HeN mice: tumour induced in C3HfeB/HeN mice expresses C3H/HeN-associated alloantigen
- PMID: 83342
- DOI: 10.1111/j.1744-313x.1978.tb00653.x
Histocompatibility difference between C3HfeB/HeN and C3H/HeN mice: tumour induced in C3HfeB/HeN mice expresses C3H/HeN-associated alloantigen
Abstract
A transplacentally induced lung tumour of C3HfeB/HeN mouse origin expresses, as a tumour-associated antigen, a normal tissue component of strain A mice. The genetic locus coding for this alloantigen has been shown to be linked to the H-2 major histocompatibility complex. In the present study we demonstrate that this antigen is also expressed on normal tissues of C3H/HeN mice. Skin grafts exchanged between C3HfeB/HeN and C3H/HeN mice are reciprocally rejected at approximately 3 weeks after grafting. C3HfeB/HeN mice were derived from C3H/HeN mice in 1945. These strains have apparently deviated since then in their genetic regulation of the expression of the MHC-linked genetic locus. The finding of the C3H/HeN-associated antigen on a C3HfeB/HeN mouse-derived lung tumour indicates that this deviation is reversible.
Similar articles
-
Lung tumor-reactive cytotoxic lymphocytes generated in mixed lymphocyte reaction between C3HfeB/HeN (H-2kb) and C3H/HeN (H-2k) strain mice.J Immunol. 1979 May;122(5):1863-6. J Immunol. 1979. PMID: 156221
-
Lung tumor-associated derepressed alloantigen coded for by the K region of the H-2 major histocompatibility complex.J Exp Med. 1978 May 1;147(5):1363-73. doi: 10.1084/jem.147.5.1363. J Exp Med. 1978. PMID: 418138 Free PMC article.
-
Variable expression and immunogenicity of an H-2K-coded alloantigen on murine tumours.J Immunogenet. 1980 Feb;7(1):31-7. doi: 10.1111/j.1744-313x.1980.tb00705.x. J Immunogenet. 1980. PMID: 7189537
-
MHC-coded unique alloantigens and antitumor immunity.Transplant Proc. 1981 Dec;13(4):1837-40. Transplant Proc. 1981. PMID: 7036480 Review. No abstract available.
-
The H-2 model for the major histocompatibility systems.Transplant Rev. 1971;6:3-29. doi: 10.1111/j.1600-065x.1971.tb00457.x. Transplant Rev. 1971. PMID: 4108876 Review. No abstract available.
Cited by
-
Biochemical comparison of H-2K antigen isolated from C3HfB/HeN and C3H/HeN mice.Immunogenetics. 1981 Mar 1;12(5-6):561-8. doi: 10.1007/BF01561696. Immunogenetics. 1981. PMID: 6783513
-
Subline divergence within L.C. Strong's C3H and CBA inbred mouse strains. A review.Immunogenetics. 1985;21(5):407-28. doi: 10.1007/BF00430926. Immunogenetics. 1985. PMID: 2987113 Review. No abstract available.
-
A novel H-2K splice form: predictions for other alternative H-2 splicing events.Immunogenetics. 1989;29(1):33-43. doi: 10.1007/BF02341611. Immunogenetics. 1989. PMID: 2908875
-
Purification of immunoprotective tumor antigens by preparative isotachophoresis.Cancer Immunol Immunother. 1983;16(2):101-8. doi: 10.1007/BF00199240. Cancer Immunol Immunother. 1983. PMID: 6559101 Free PMC article.
-
Lymphocytes express Ia antigens of foreign haplotype following treatment with neuraminidase.Immunogenetics. 1981;12(1-2):1-20. doi: 10.1007/BF01561647. Immunogenetics. 1981. PMID: 6937436 No abstract available.
MeSH terms
Substances
LinkOut - more resources
Research Materials