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. 1993 Aug;61(8):3530-2.
doi: 10.1128/iai.61.8.3530-3532.1993.

Enhancement of susceptibility of CB-17 mice to systemic candidiasis by poly(I . C)-induced interferon

J Jensen  1 , E Balish
Affiliations

Enhancement of susceptibility of CB-17 mice to systemic candidiasis by poly(I . C)-induced interferon

J Jensen et al. Infect Immun. 1993 Aug.

Abstract

Poly(I . C) enhanced the susceptibility of CB-17 (BALB/c) mice to acute systemic candidiasis. Poly(I . C), supernatants from poly(I . C)-treated macrophages, or alpha and beta interferons suppressed macrophage candidacidal activity in vitro. Thus, poly(I . C)-induced interferons may enhance the susceptibility of CB-17 mice to candidiasis by suppressing macrophage candidacidal activity in an autocrine fashion.

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