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. 1993 Aug;61(8):3565-9.
doi: 10.1128/iai.61.8.3565-3569.1993.

Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon

P P Manna  1 , D Bharadwaj, S Bhattacharya, G Chakrabarti, D Basu, K K Mallik, S Bandyopadhyay
Affiliations

Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon

P P Manna et al. Infect Immun. 1993 Aug.

Abstract

Indian kala-azar patients have normal numbers of peripheral blood NK cells but impaired functional activity due to decreased binding and lysis of target cells. This impairment of NK activity could not be corrected by exogenous recombinant human alpha or gamma interferon. However, recombinant human interleukin 2 was able to restore this activity by augmenting conjugate formation and lysis of target cells.

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