Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Aug;61(8):3565-9.
doi: 10.1128/iai.61.8.3565-3569.1993.

Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon

P P Manna  1 , D Bharadwaj, S Bhattacharya, G Chakrabarti, D Basu, K K Mallik, S Bandyopadhyay
Affiliations

Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon

P P Manna et al. Infect Immun. 1993 Aug.

Abstract

Indian kala-azar patients have normal numbers of peripheral blood NK cells but impaired functional activity due to decreased binding and lysis of target cells. This impairment of NK activity could not be corrected by exogenous recombinant human alpha or gamma interferon. However, recombinant human interleukin 2 was able to restore this activity by augmenting conjugate formation and lysis of target cells.

PubMed Disclaimer

References

    1. Nature. 1979 Mar 29;278(5703):451-3 - PubMed
    1. Trans R Soc Trop Med Hyg. 1991 Jan-Feb;85(1):54-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Aug;77(8):4914-7 - PubMed
    1. J Immunol. 1981 Sep;127(3):1024-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 May;79(10):3275-9 - PubMed

Publication types

LinkOut - more resources