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. 1993 Aug;29(2 Pt 1):181-4.
doi: 10.1016/0190-9622(93)70164-o.

Bullous pemphigoid and autoimmunity

G Taylor  1 , V Venning, F Wojnarowska, K Welch
Affiliations

Bullous pemphigoid and autoimmunity

G Taylor et al. J Am Acad Dermatol. 1993 Aug.

Abstract

Background: There are many case reports of bullous pemphigoid (BP) in association with a variety of autoimmune disorders, but no large case controlled studies have been performed.

Objective: Our purpose was to determine whether there is an increased incidence of autoimmune disorders in patients with BP and whether there is a particular haplotype associated with this.

Methods: A total of 108 patients with BP were studied and compared with a group of 108 age- and sex-matched controls. HLA typing at the A, B, C, and DR loci was performed on 55 of the 108 patients with BP.

Results: The difference in incidence of autoimmune disorders between patients and controls was not significant. The haplotypes of patients with BP were similar to those of a locally drawn population.

Conclusion: There is no increase in the incidence of autoimmune disorders in BP, and no particular haplotype appears to be associated with a predisposition to this condition.

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