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. 1993 Jul 9;36(14):1971-6.
doi: 10.1021/jm00066a006.

Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus

R J Ternansky  1 , S E Draheim, A J Pike, F W Bell, S J West, C L Jordan, C Y Wu, D A Preston, W Albron Jr, J S Kasher, et al.
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Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus

R J Ternansky et al. J Med Chem. .

Abstract

The synthesis and antimicrobial activity of several new 1-carba-1-dethiacephalosporins is described. The discovery of unique activity of some of the analogues against methicillin-resistant Staphylococcus aureus led to the development of a structure-activity relationship designed to optimize this activity. The results of this investigation along with the pharmacokinetic characteristics of select compounds are described.

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