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. 1977 Jan;66(1):142-4.
doi: 10.1002/jps.2600660144.

High-pressure liquid chromatographic analysis of drugs in biological fluids I. Warfarin

T D Bjornsson, T F Blaschke, P J Meffin

High-pressure liquid chromatographic analysis of drugs in biological fluids I. Warfarin

T D Bjornsson et al. J Pharm Sci. 1977 Jan.

Abstract

A rapid, sensitive, and specific high-pressure liquid chromatographic (HPLC) method for the quantitative analysis of warfarin in plasma is described. The method involves a single solvent extraction of warfarin and the internal standard form acidified plasma, followed by evaporation and HPLC analysis. The method is sufficiently sensitive and accurate for most pharmacokinetic studies: concentrations between 0.1 and 4.0 mug/ml can be measured with a coefficient of variation of 2-5%. Known metabolites of warfarin do not interfere with the analysis.

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