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. 1993 Jul;265(1 Pt 1):C299-303.
doi: 10.1152/ajpcell.1993.265.1.C299.

cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells

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cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells

B E Robertson et al. Am J Physiol. 1993 Jul.

Abstract

Guanosine-3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (cGMP-PK) plays a central role in the mediation of the vasodilator response to nitric oxide (NO) and other nitrovasodilators. It is unclear whether cGMP-PK affects calcium-activated potassium channels (KCa channels) or any other type of ion channel in smooth muscle. We provide here the first direct evidence that cGMP-PK can activate KCa channels in arterial smooth muscle cells. We demonstrate that NO and a membrane-permeable analogue of cGMP can activate KCa channels in on-cell patches approximately twofold. Furthermore, cGMP-PK, in the presence of ATP and cGMP added directly to the intracellular surface of inside-out patches, increases channel activity by approximately eightfold. These results suggest that cGMP-PK-mediated activation of KCa channels may contribute to the actions of NO and other nitrovasodilators.

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