doi: 10.1007/BF01469088.
Human mammary cancers in nu/nu-mice. A model for testing in research and clinic
- PMID: 834020
- DOI: 10.1007/BF01469088
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Human mammary cancers in nu/nu-mice. A model for testing in research and clinic
Klin Wochenschr.
.
Abstract
37 (85%) of 44 human breast cancers are successfully transplanted on thymus-aplastic nu/nu-mice without adjunctive immunotherapy. 16 weeks after transplantation 4 rapidly growing tumours are showing human, female karyotypes. Subsequent investigations proved a good correlation between original tumour and transplant: histology, 3H-thymidine marking index and receptors of androgen and estorgen.
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