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. 1977 Jan 15;55(2):83-4.
doi: 10.1007/BF01469088.

Human mammary cancers in nu/nu-mice. A model for testing in research and clinic

G Bastert, H Schmidt-Matthiesen, R T Michel, H P Fortmeyer, R Sturm, D Nord, R Gerner

Human mammary cancers in nu/nu-mice. A model for testing in research and clinic

G Bastert et al. Klin Wochenschr. .

Abstract

37 (85%) of 44 human breast cancers are successfully transplanted on thymus-aplastic nu/nu-mice without adjunctive immunotherapy. 16 weeks after transplantation 4 rapidly growing tumours are showing human, female karyotypes. Subsequent investigations proved a good correlation between original tumour and transplant: histology, 3H-thymidine marking index and receptors of androgen and estorgen.

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