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. 1993 Apr;18(1):119-22.
doi: 10.1016/s0168-8278(05)80019-4.

Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France

C Féray  1 , M Gigou, D Samuel, J Bernuau, H Bismuth, C Bréchot
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Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France

C Féray et al. J Hepatol. 1993 Apr.

Abstract

The presence of mutants of the precore region of the hepatitis B virus genome was investigated in French patients with fulminant hepatitis. Only one of the 10 subjects had a detectable mutation by direct sequencing. On the other hand, 2/10 and 3/10 had evidence of coinfection by hepatitis D virus and hepatitis C virus. These results indicate that the precore stop mutation at codon 28 is not a general condition in fulminant hepatitis B and might reflect epidemiological factors.

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