doi: 10.1111/j.1539-6924.1993.tb01078.x.
How tautological are interspecies correlations of carcinogenic potencies?
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- PMID: 8341805
- DOI: 10.1111/j.1539-6924.1993.tb01078.x
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How tautological are interspecies correlations of carcinogenic potencies?
Risk Anal.
1993 Jun.
Abstract
Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al., however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. have a comeback. This paper will review the arguments and present some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al.
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