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. 1993 Aug;36(8):1137-41.
doi: 10.1002/art.1780360815.

Antihistone antibodies in patients with localized scleroderma

S Sato  1 , H Ihn, Y Soma, A Igarashi, T Tamaki, K Kikuchi, Y Ishibashi, K Takehara
Affiliations

Antihistone antibodies in patients with localized scleroderma

S Sato et al. Arthritis Rheum. 1993 Aug.

Abstract

Objective: To study the prevalence and antigen specificity of antihistone antibodies (AHA) in localized scleroderma.

Methods: Forty-nine serum samples from patients with localized scleroderma were examined by an enzyme-linked immunosorbent assay (ELISA) and by immunoblotting.

Results: By ELISA, AHA were demonstrated in 47% (23 of 49) of patients with localized scleroderma and in 87% (13 of 15) of patients with generalized morphea. Immunoblotting revealed that the predominant antigens were histones H1 and H3. The presence of AHA correlated with that of anti-single-stranded DNA antibody.

Conclusion: Some of the major antigens for antinuclear antibodies in patients with localized scleroderma are histones.

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