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. 1993 Jul 30;74(2):299-307.
doi: 10.1016/0092-8674(93)90421-l.

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine

X Cheng  1 , S Kumar, J Posfai, J W Pflugrath, R J Roberts
Affiliations

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine

X Cheng et al. Cell. .

Abstract

The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.

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