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. 1993 Aug 9;328(1-2):17-20.
doi: 10.1016/0014-5793(93)80956-u.

Spleen-derived growth factor, SDGF-3, is identified as keratinocyte growth factor (KGF)

M Suzuki  1 , T Itoh, H Osada, J S Rubin, S A Aaronson, T Suzuki, N Koga, T Saito, Y Mitsui
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Free article

Spleen-derived growth factor, SDGF-3, is identified as keratinocyte growth factor (KGF)

M Suzuki et al. FEBS Lett. .
Free article

Abstract

A heparin-binding mitogen rat for rat hepatocytes was partially purified from bovine spleen by a combination of heparin-affinity, cation-exchange and gel-filtration chromatography. Besides stimulating rat hepatocytes, this factor, which was designated spleen-derived growth factor-3 (SDGF-3), exhibited mitogenic activity for mouse epidermal keratinocytes but not mouse fibroblasts. Its apparent epithelial specificity and heparin-binding properties corresponded to those of keratinocyte growth factor (KGF). These findings, together with the fact that the mitogenic activity of SDGF-3 was abolished by a neutralizing monoclonal antibody specific for KGF, identify this bovine spleen-derived hepatocyte mitogen as KGF.

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