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. 1993 Apr:21 Suppl 1:38-40.

[Circadian rhythm in cytokines]

[Article in German]
P Zabel  1 , K Linnemann, M Schlaak
Affiliations
  • PMID: 8344688

[Circadian rhythm in cytokines]

[Article in German]
P Zabel et al. Immun Infekt. 1993 Apr.

Abstract

The well-known human circadian rhythm (CR) in body temperature may be due to CR in endogenous pyrogens such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF). We, therefore, investigated the daily variation in spontaneous and LPS-induced monokine release by peripheral blood cells (whole blood assay) in 10 healthy volunteers. Spontaneous release of monokines (IL-1, IL-6, TNF) showed a simultaneous significant peak at noon, whereas LPS-induced release of IL-1 and IL-6 was strictly correlated with the CR in body temperature with its significant maximum at 8.00 p.m. Since LPS-induced release of TNF showed a significant peak at 4.00 a.m., interleukins and TNF seem to be independently regulated. CR in IL-1 and IL-6 release are suggested to be responsible for the CR in body temperature.

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