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. 1993 Jun;8(6):903-7.
doi: 10.1093/oxfordjournals.humrep.a138163.

Immediate rearrangements of human sperm chromosomes following in-vivo irradiation

S Rousseaux  1 , B Sèle, J Cozzi, E Chevret
Affiliations

Immediate rearrangements of human sperm chromosomes following in-vivo irradiation

S Rousseaux et al. Hum Reprod. 1993 Jun.

Abstract

The short-term effects of radiotherapy on sperm chromosomes was evaluated in two Hodgkin patients. Sperm cytogenetics were analysed by using human-hamster cross-fertilization. Immediately after irradiation, most sperm metaphases from the first patient exhibited multiple rearrangements, whereas in the second one, the incidence of such abnormalities was only slightly increased. Multi-fragmented chromosomes and structural aberrations of the chromatid-type were observed, suggesting a specific immediate response.

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