Case Reports
doi: 10.1016/s0022-3476(05)81713-5.
Death from a morphine infusion during a sickle cell crisis
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- PMID: 8345436
- DOI: 10.1016/s0022-3476(05)81713-5
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Case Reports
Death from a morphine infusion during a sickle cell crisis
J Pediatr.
1993 Aug.
Abstract
A 15-year-old boy died during a vaso-occlusive sickle cell crisis after having received a prolonged infusion of morphine. Even in therapeutic doses, narcotics may cause significant respiratory acidosis and hypoxemia, enhancing polymerization of hemoglobin SS and thereby promoting sickling and vaso-occlusion. When narcotics are used during a sickle cell crisis, the best method is pharmacokinetically based patient-controlled analgesia.
Comment in
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Morphine therapy for sickle cell crisis.J Pediatr. 1994 Jul;125(1):175-6. doi: 10.1016/s0022-3476(94)70165-2. J Pediatr. 1994. PMID: 8021778 No abstract available.
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Pain relief during sickle cell crisis.J Pediatr. 1994 Jan;124(1):162-3. doi: 10.1016/s0022-3476(94)70286-1. J Pediatr. 1994. PMID: 8283370 No abstract available.
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