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Comparative Study
. 1993 Jul;52(7):539-41.
doi: 10.1136/ard.52.7.539.

Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community

W Thomson  1 , L Pepper, A Payton, D Carthy, D Scott, W Ollier, A Silman, D Symmons
Affiliations
Comparative Study

Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community

W Thomson et al. Ann Rheum Dis. 1993 Jul.

Abstract

Objectives: To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis.

Methods: HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis.

Results: The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18%).

Conclusions: The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.

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