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Review
. 1993 Apr;278(2-3):359-64.

Bacterial adherence and epithelial cell cytokine production

C Svanborg  1 , W Agace, S Hedges, H Linder, M Svensson
Affiliations
  • PMID: 8347939
Review

Bacterial adherence and epithelial cell cytokine production

C Svanborg et al. Zentralbl Bakteriol. 1993 Apr.

Abstract

Epithelial cell lines produce the cytokines IL-1 alpha, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.

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