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. 1993 Aug 13;74(3):577-84.
doi: 10.1016/0092-8674(93)80058-m.

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

J C Shepherd  1 , T N Schumacher, P G Ashton-Rickardt, S Imaeda, H L Ploegh, C A Janeway Jr, S Tonegawa
Affiliations

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

J C Shepherd et al. Cell. .

Erratum in

  • Incorrect attribution of peptide source.
    Eisen HN, Tsomides T, Udaka K, Walden P, Fukusen N. Eisen HN, et al. Cell. 1993 Nov 19;75(4):613. doi: 10.1016/0092-8674(93)90481-5. Cell. 1993. PMID: 8242737 No abstract available.

Abstract

T cells detect infection of cells by recognizing peptide fragments of foreign proteins bound to class I molecules of the major histocompatibility complex (MHC) on the surface of the infected cell. MHC class I molecules bind peptide in the endoplasmic reticulum, and analysis of mutant cells has demonstrated that an adequate supply of peptides requires the presence of two genes in the MHC class II locus that encode proteins called transporters associated with antigen processing (TAP) 1 and 2. TAP1 and TAP2 are members of the ATP-binding cassette family of membrane translocators. In this study, we demonstrate in a cell-free system that TAP1 is part of an ATP-dependent, sequence-specific, peptide translocator.

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