doi: 10.1126/science.835006.
13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat
- PMID: 835006
- DOI: 10.1126/science.835006
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13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat
Science.
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Abstract
Transitional cell and squamous cell cancer of the bladder was induced in Wistar/Lewis female rats by direct instillation of N-methyl-N-nitrosourea into the bladder. Feeding of the synthetic retinoid, 13-cis-retinoid acid, inhibited the incidence and extent of bladder cancer in these rats, even when 13-cis-retinoic acid administration was begun after completion of the carcinogen treatment.
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