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. 1977 Feb 4;195(4277):487-9.
doi: 10.1126/science.835006.

13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat

M B Sporn, R A Squire, C C Brown, J M Smith, M L Wenk, S Springer

13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat

M B Sporn et al. Science. .

Abstract

Transitional cell and squamous cell cancer of the bladder was induced in Wistar/Lewis female rats by direct instillation of N-methyl-N-nitrosourea into the bladder. Feeding of the synthetic retinoid, 13-cis-retinoid acid, inhibited the incidence and extent of bladder cancer in these rats, even when 13-cis-retinoic acid administration was begun after completion of the carcinogen treatment.

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