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Clinical Trial
. 1993 Jun;20(6):950-2.

Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: an 8 week randomized placebo controlled trial

M E Weinblatt  1 , A L Maier, J S Coblyn
Affiliations
  • PMID: 8350329
Clinical Trial

Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: an 8 week randomized placebo controlled trial

M E Weinblatt et al. J Rheumatol. 1993 Jun.

Abstract

Objective: To determine if simultaneously administered low dose leucovorin interferes with the efficacy of methotrexate (MTX).

Methods: An 8-week double blind placebo controlled study of leucovorin (1 mg) in 16 patients with rheumatoid arthritis receiving chronic MTX was performed at a single academic center.

Results: A flare of disease activity was not observed. Clinical variables of arthritis activity did not change in the leucovorin treated population.

Conclusions: Low dose leucovorin when taken simultaneously with MTX did not interfere with the efficacy of MTX in a short term 8 week trial.

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