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Clinical Trial
. 1993 Aug;43(8):1609-11.
doi: 10.1212/wnl.43.8.1609.

Clinical trial of indomethacin in Alzheimer's disease

J Rogers  1 , L C Kirby, S R Hempelman, D L Berry, P L McGeer, A W Kaszniak, J Zalinski, M Cofield, L Mansukhani, P Willson, et al.
Affiliations
Clinical Trial

Clinical trial of indomethacin in Alzheimer's disease

J Rogers et al. Neurology. 1993 Aug.

Abstract

In a 6-month, double-blind, placebo-controlled study, 100 to 150 mg/d indomethacin appeared to protect mild to moderately impaired Alzheimer's disease patients from the degree of cognitive decline exhibited by a well-matched, placebo-treated group. Over a battery of cognitive tests, indomethacin patients improved 1.3% (+/- 1.8%), whereas placebo patients declined 8.4% (+/- 2.3%)--a significant difference (p < 0.003). Caveats include adverse reactions to indomethacin and the limited scale of the trial.

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