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. 1993 Jul-Aug;13(4):901-4.

A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer

X Fu  1 , P Le, R M Hoffman
Affiliations
  • PMID: 8352558

A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer

X Fu et al. Anticancer Res. 1993 Jul-Aug.

Abstract

We report here the development of an orthotopic-transplant model of human patient breast cancer in nude mice. Histologically-intact patient breast tumor tissue was transplanted as intact tissue to the mammary fat pad of nude mice where the tumor tissue grew extensively and metastasized to the lung. This is the first orthotopic-transplant metastatic model of human breast cancer. The potential clinical and basic-science uses of the model are discussed.

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