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. 1993 Sep;68(3):460-4.
doi: 10.1038/bjc.1993.370.

Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours

M Santoro  1 , N Sabino, Y Ishizaka, T Ushijima, F Carlomagno, A Cerrato, M Grieco, C Battaglia, M L Martelli, C Paulin, et al.
Affiliations
Free PMC article

Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours

M Santoro et al. Br J Cancer. 1993 Sep.
Free PMC article

Abstract

Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas.

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