[Longterm therapy with i.v.-gamma-globulin in children (author's transl)]

Abstract

gamma-Globulin for treatment should be injected by the intravenous route whenever possible. An unsplit molecule would be of great advantage in this context but there is the problem of antigenicity. One possibility to attain a good tolerance for i.v.-gamma-globin is to treat the molecule with beta-propiolactone. The acute tolerance and the efficacy of this preparation are proven. We wanted to find out if the modification of the immunoglobulin by beta-propiolactone would induce new antigene properties, which could lead to antibody production after repeated injections. There were no antibodies to be found neither in vivo nor in vitro in 6 children, which received 8--166 injections of this preparation.