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Review
. 1993 Jun;3(3):390-7.
doi: 10.1016/0959-437x(93)90110-b.

Mammalian chromosome structure

C Tyler-Smith  1 , H F Willard
Affiliations
Review

Mammalian chromosome structure

C Tyler-Smith et al. Curr Opin Genet Dev. 1993 Jun.

Abstract

The DNA sequences that are necessary for the formation of a functional mammalian chromosome are thought to be the origins of replication, the telomeres and the centromere. Telomere structure is now well understood, with the functional element characterized as the motif (TTAGGG)n. The structures of the DNA regions that contain origins of replication and a centromere are known, but the functionally important elements within these regions are still only poorly defined.

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