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. 1993 Aug 27;261(5125):1169-71.
doi: 10.1126/science.8356450.

Identification of a structural glycoprotein of an RNA virus as a ribonuclease

R Schneider  1 , G Unger, R Stark, E Schneider-Scherzer, H J Thiel
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Identification of a structural glycoprotein of an RNA virus as a ribonuclease

R Schneider et al. Science. .

Abstract

One of the three structural glycoproteins of classical swine fever virus (CSFV) is E0, a disulfide-bonded homodimer that induces virus-neutralizing antibodies and occurs in a virion-bound as well as a secreted form. E0 was shown to be similar to a family of fungal and plant ribonucleases. Purified E0 from CSFV-infected cells was a potent ribonuclease specific for uridine and inhibitable by zinc ions.

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