Cell surface antigens containing beta2-microglobulin as the common subunit

Abstract

beta2-Microglobulin, which was first discovered in various biological fluids, has been shown to be the common subunit of the human HLA-A,B,C antigens. In the mouse beta2-microglobulin is associated with H-2K, D and L antigens and with TL and Qa-2 antigens, beta2-microglobulin and the heavy HLA antigen chains are similar in structure to the immunoglobulins and it is suggested that the two types of molecules have had an interrelated evolution. Data are also presented which suggest that the structural similarity between transplantation antigens and immunoglobulins may be paralleled by a functional similarity as well.