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. 1993 Aug 19;1174(2):201-3.
doi: 10.1016/0167-4781(93)90116-u.

The nucleotide sequence of human aminoacylase-1

M Mitta  1 , I Kato, S Tsunasawa
Affiliations

The nucleotide sequence of human aminoacylase-1

M Mitta et al. Biochim Biophys Acta. .

Abstract

The nucleotide sequence of a cDNA coding for human aminoacylase-1 (N-acylamino acid aminohydrolase, ACY-1, EC 3.5.1.14) subunit has been determined. The amino acid sequence of human ACY-1 subunit deduced from its cDNA nucleotide sequence showed a high degree of identity (87.7%) with the corresponding protein from porcine [1], although the former is one amino acid residue longer than the latter. Of 12 histidine and 3 cysteine residues, conserved between the proteins from two species, some are anticipated to form the active site of ACY-1 as either catalytic residues or ligands for an essential Zn2+ atom.

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