Tetrafibricin, a novel fibrinogen receptor antagonist. II. Structural elucidation
- PMID: 8360098
- DOI: 10.7164/antibiotics.46.1047
Tetrafibricin, a novel fibrinogen receptor antagonist. II. Structural elucidation
Abstract
The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaensis NR0577, was determined. Tetrafibricin has a unique structure containing primary amine, conjugated tetraenoic acid, and polyhydroxy functionalities that is biosynthetically related to the polyene macrolide antibiotics.
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