doi: 10.7164/antibiotics.46.1082.
Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum
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- PMID: 8360103
- DOI: 10.7164/antibiotics.46.1082
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Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum
J Antibiot (Tokyo).
1993 Jul.
Free article
Abstract
Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.
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