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. 1993 Jul;46(7):1082-8.
doi: 10.7164/antibiotics.46.1082.

Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum

F Mayerl  1 , Q Gao, S Huang, S E Klohr, J A Matson, D R Gustavson, D M Pirnik, R L Berry, C Fairchild, W C Rose
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Free article

Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum

F Mayerl et al. J Antibiot (Tokyo). 1993 Jul.
Free article

Abstract

Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.

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