Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Jul;46(1-2):25-31.
doi: 10.1016/0165-5728(93)90230-v.

Trafficking of activated cytotoxic T lymphocytes into the central nervous system: use of a transgenic model

M B Oldstone  1 , P J Southern
Affiliations

Trafficking of activated cytotoxic T lymphocytes into the central nervous system: use of a transgenic model

M B Oldstone et al. J Neuroimmunol. 1993 Jul.

Abstract

We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or beta cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS.

PubMed Disclaimer

References

    1. Campbell I.L., Oldstone M.B.A., Mucke L. Society for Neuroscience; Anaheim, CA: 1992. Neurologic disease induced in transgenic mice by the astrocyte-specific expression of interleukin-6. October 25–30.
    1. Chan W., Javanovic T., Lukie M. Infiltration of immune T cells in the brain of mice with herpes simplex virus-induced encephalitis. J. Neuroimmunol. 1989;23:195. - PMC - PubMed
    1. De la Torre J.C., Oldstone M.B.A. Vol. 89. 1992. Selective disruption of growth hormone transcription machinery by viral infection; pp. 9939–9943. (Proc. Natl. Acad. Sci. USA). - PMC - PubMed
    1. Dutko F.J., Oldstone M.B.A. Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains. J. Gen. Virol. 1983;64:1689–1689. - PubMed
    1. Falk K., Rotzscke O., Stevanovie S. Allele-specific motifs rrevealed by sequncing of self-peptides eluted from MHC molecules. Nature. 1991;351:290–296. - PubMed

Publication types