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. 1993 Aug 15;294 ( Pt 1)(Pt 1):301-4.
doi: 10.1042/bj2940301.

Effect of lead acetate and carbon particles on the expression of glutathione S-transferase YfYf in rat liver

S J Boyce  1 , T J Mantle
Affiliations

Effect of lead acetate and carbon particles on the expression of glutathione S-transferase YfYf in rat liver

S J Boyce et al. Biochem J. .

Abstract

Administration of intracardiac lead acetate produces a complex response in glutathione S-transferase (GST) YfYf expression in rat liver. The earliest response, an elevation of GST expression in Kupffer cells, can be mimicked by administering a suspension of carbon particles. The second effect of lead acetate administration is a marked elevation of GST YfYf in some but not all hepatocytes (the 'patchy' response). This effect is most marked 48-76 h after administration of a single dose of lead acetate and is easily detected by immunoblotting. Dexamethasone down-regulates the lead response in hepatocytes.

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