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Review
. 1993 Jul;14(7):353-6.
doi: 10.1016/0167-5699(93)90235-D.

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

T G Wegmann  1 , H Lin, L Guilbert, T R Mosmann
Affiliations
Review

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

T G Wegmann et al. Immunol Today. 1993 Jul.

Abstract

Pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell-mediated immunity. Since TH1 cytokines compromise pregnancy and TH2 cytokines are produced at the maternal-fetal interface, we hypothesize that these TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens.

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Comment in

  • Cytokines and the maternal-fetal interface.
    Moncayo HE, Solder E, Abfalter E, Moncayo R. Moncayo HE, et al. Immunol Today. 1994 Jun;15(6):295. doi: 10.1016/0167-5699(94)90010-8. Immunol Today. 1994. PMID: 8068176 No abstract available.

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