Effect of co-aggregation on the pathogenicity of oral bacteria
- PMID: 8366516
- DOI: 10.1099/00222615-39-3-183
Effect of co-aggregation on the pathogenicity of oral bacteria
Abstract
The pathogenicity of oral bacteria was studied by measuring the development of subcutaneous abscesses in mice after infection with Actinomyces viscosus and Streptococcus mitis either singly or as co-aggregated pairs. Heat-treated cells were also tested. The pathogenicity of the co-aggregates was examined in various viable and heat-treated combinations of the two bacterial species. More abscesses were formed by A. viscosus than S. mitis at all the bacterial concentrations tested. Also, abscess formation by co-aggregates of the two strains produced a higher percentage of abscess formation than those caused by infection with pure suspensions of A. viscosus or S. mitis. Co-aggregated cells were more resistant to phagocytosis and killing by neutrophils in vitro and in vivo. Furthermore, A. viscosus in co-aggregates were resistant to killing after engulfment by neutrophils. These results suggest that oral bacteria that are able to co-aggregate may resist phagocytosis, and this ability may be linked with pathogenicity.
Similar articles
-
Co-aggregation as a virulent factor of Streptococcus sanguis isolated from infective endocarditis.J Oral Sci. 1999 Sep;41(3):117-22. doi: 10.2334/josnusd.41.117. J Oral Sci. 1999. PMID: 10692836
-
Plaque formation and implantation of Odontomyces viscosus in hamsters fed different carbohydrates.J Dent Res. 1969 Sep-Oct;48(5):824-31. doi: 10.1177/00220345690480053601. J Dent Res. 1969. PMID: 5259424 No abstract available.
-
Powdered milk micellar casein prevents oral colonization by Streptococcus sobrinus and dental caries in rats: a basis for the caries-protective effect of dairy products.Caries Res. 1999 Nov-Dec;33(6):446-54. doi: 10.1159/000016550. Caries Res. 1999. PMID: 10529530
-
Dental caries.Annu Rev Med. 1975;26:121-36. doi: 10.1146/annurev.me.26.020175.001005. Annu Rev Med. 1975. PMID: 1096752 Review. No abstract available.
-
Intrageneric and Intergeneric Interactions Developed by Oral Streptococci: Pivotal Role in the Pathogenesis of Oral Diseases.Curr Issues Mol Biol. 2019;32:377-434. doi: 10.21775/cimb.032.377. Epub 2019 Jun 5. Curr Issues Mol Biol. 2019. PMID: 31166176 Review.
Cited by
-
A Case of Empyema Due to Actinomyces odontolyticus and Streptococcus Species Co-infection in an Immunocompetent Woman.Cureus. 2022 Dec 19;14(12):e32700. doi: 10.7759/cureus.32700. eCollection 2022 Dec. Cureus. 2022. PMID: 36686073 Free PMC article.
-
The Escherichia coli efflux pump TolC promotes aggregation of enteroaggregative E. coli 042.Infect Immun. 2008 Mar;76(3):1247-56. doi: 10.1128/IAI.00758-07. Epub 2007 Dec 26. Infect Immun. 2008. PMID: 18160483 Free PMC article.
-
Conformation change in a self-recognizing autotransporter modulates bacterial cell-cell interaction.J Biol Chem. 2010 Apr 2;285(14):10616-26. doi: 10.1074/jbc.M109.069070. Epub 2010 Feb 1. J Biol Chem. 2010. PMID: 20123991 Free PMC article.
-
Cooperative plasminogen recruitment to the surface of Streptococcus canis via M protein and enolase enhances bacterial survival.mBio. 2013 Mar 12;4(2):e00629-12. doi: 10.1128/mBio.00629-12. mBio. 2013. PMID: 23481605 Free PMC article.
-
Tandem Mass Tag-Based Quantitative Proteomics and Virulence Phenotype of Hemolymph-Treated Bacillus thuringiensis kurstaki Cells Reveal New Insights on Bacterial Pathogenesis in Insects.Microbiol Spectr. 2021 Oct 31;9(2):e0060421. doi: 10.1128/Spectrum.00604-21. Epub 2021 Oct 27. Microbiol Spectr. 2021. PMID: 34704785 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical