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Clinical Trial
. 1993 Jul 10;111(19):339-42.

[St. John's wort extract in the ambulatory therapy of depression. Attention and reaction ability are preserved]

[Article in German]
U Schmidt  1 , H Sommer
Affiliations
  • PMID: 8370566
Clinical Trial

[St. John's wort extract in the ambulatory therapy of depression. Attention and reaction ability are preserved]

[Article in German]
U Schmidt et al. Fortschr Med. .

Abstract

Method: In a placebo-controlled, randomized, double-blind trial involving outpatients with mild to moderately severe depression, an extract of St. John's wort (Hypericum), LI 160, a herbal antidepressant was tested for efficacy and tolerability, as well as for possible negative effects on cognitive performance.

Results: The responder rate to treatment with the extract was 66.6% as compared with only 26.7% with placebo. The treatment was very well tolerated; only in two patients did transient minor side effects occur under LI 160. No impairment of cognitive performance was observed: during the trial, Hypericum did not lead to any impairment of attention, concentration or reaction.

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