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. 1993 Jun;62(2):207-10.
doi: 10.1254/jjp.62.207.

Marked species-difference in the vascular angiotensin II-forming pathways: humans versus rodents

H Okunishi  1 , Y Oka, N Shiota, T Kawamoto, K Song, M Miyazaki
Affiliations
Free article

Marked species-difference in the vascular angiotensin II-forming pathways: humans versus rodents

H Okunishi et al. Jpn J Pharmacol. 1993 Jun.
Free article

Abstract

Using isolated arteries, we demonstrated a marked difference in the angiotensin II-forming systems between human and rodent vessels. In human arteries, only 30-40% of the conversion of angiotensin I to angiotensin II depended on the angiotensin-converting enzyme (ACE), and the rest of the angiotensin II formation was ascribed to chymostatin-sensitive angiotensin II-generating enzyme (CAGE). On the contrary, angiotensin II formation in rodent arteries totally depended upon ACE, without any sign of CAGE involvement. Such a marked species-difference can be relevant to the reported difference between humans and rodents in the ACE inhibitor effects on the myointimal hyperplasia after intimal balloon injury.

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